NAD+ Research | European NAD+ Therapy Pioneers

Nicotinamide Adenine Dinucleotide (NAD+)

NAD+ is a compound which is found in all living cells. This small molecule is a core essential for life. It plays many essential roles during the metabolic process, where it turns nutrients into energy.

As we get older, the levels of NAD+ in our bodies start to decline; however, researchers have found ways to boost the NAD+ levels in the body through supplementation. Studies have shown many health benefits associated with nicotinamide riboside; it has shown significant results in maintaining robust health and preventing problems which accompany ageing.

NAD+ Explained

According to, NAD+ (nicotinamide adenine dinucleotide) is an essential part of life. It is a co-enzyme which is found in all living cells, just as important to us as the air we breathe and the food we eat.

Science has shown that NAD+ levels start to decrease as we get older; the higher our levels of NAD+ are, the better our cells function. Scientists believe that our health and lifespan can be improved with a supplementation of nicotinamide adenine dinucleotide.

NAD Guide
NAD Guide
NAD+ History
NAD+ History

NAD+ History

NAD+ was discovered in 1906 by two British biochemists, Arthur Harden and William John Young. The importance and medical benefits were established when a disease called pellagra was discovered, which is caused by a severe lack of vitamin B3. Typical symptoms include diarrhoea, inflamed skin, mouth sores and even dementia. Pellagra can be fatal if left untreated. Although not a common disease, NAD+ has proven helpful in halting age-associated diseases and assisting with the slowing down of the ageing process.

NAD+ has been administered as early as the 1930s. It has been found to improve the neurological state of dementia patients and to provide dramatic therapeutic benefits for diseases such as schizophrenia, colitis, rheumatoid arthritis, diabetes and muscular sclerosis (MS).

Recent Science Supports the Benefits of NAD+

While it has been around for more than a century, only in recent years have some major discoveries surrounding NAD+ been made. While we are aware of the involvement of NAD+ with increasing energy, metabolism and mitochondrial functions, it has recently been discovered that NAD+ has been linked with DNA repair and can assist in the longevity of life.

Amongst these discoveries, it was found that NAD+ levels slowly decline as we age, meaning the processes within the body, which require NAD+, may not function properly as we get older.

An American biologist, Dr Leonard Guarente, discovered that a family of proteins which keep our cells in homeostasis, governing longevity, only functioned when NAD+ was present.

In a recent study, “NAD+ metabolism and oxidative stress”,  it was found that NAD+ was identified as a very important factor in cellular respiration, generating energy production and playing a somewhat unique role in the repairing of DNA. NAD+ plays a significant role in oxidative stress, immune activation, cell viability in neurodegenerative disorders and energy metabolism. Administering NAD+ into the body can effectively regulate stress resistance and cell death, which are associated with age-related disorders. Studies show that as human beings, our goal is to stay in a state of balance- a state of homeostasis, made possible by specific proteins and coenzymes.

Sirtuins, What are they?

Sirtuin-rich foods have proven to provide an array of heath benefits, including improving life quality and longevity. Sirtuins are a family of age-related proteins that help reduce inflammation and regulate metabolism and are linked with improving cellular death. Sirtuins can also improve the functions of memory formation and modulate the plasticity of the brain.



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